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Necroptosis in CNS diseases: focus on astrocytes

KEAP1, which promotes the ubiquitination and subsequent degradation of NRF2, a key regulator of the antioxidant response, was upregulated in chemotherapy-sensitive tumors, suggesting that targeting the NRF2KEAP1 pathway could enhance the sensitivity of MIBC cells to cisplatin

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8,9 More than 130 articles from MEDLINE related to oxidative stress and antioxidants during 19902014 revealed that the imbalance between the formation of oxidants and the availability of endogenous antioxidants are the major determinant of endometriosis